An oocyte (egg!) is a female germ cell involved in reproduction. It is one of the largest cells in the body with a diameter of at least 100 μm when mature.

Good egg quality is a prerequisite for successful fertilization, implantation, and development of a new human being.


A large proportion of eggs are capable of being fertilized, but only approximately half of fertilized eggs fully complete their preimplantation development and still fewer implant.

Several studies have suggested that some gene expression levels could serve as oocyte quality markers.

Additionally, recent studies also confirmed that egg-like cells expressing some egg-specific genes can be developed in vitro from different types of stem cells.

These include human embryonic stem cells (hESCs), human induced pluripotent stem cells (hiPSCs), putative stem cells from adult human ovaries of women with no naturally present follicles or oocytes, and human amniotic fluid stem cells (hAFSCs).

The aim of this interesting paper I found here is to summarize the new knowledge on the gene expression profile of human eggs developed and matured in vivo and in vitro.